PARANEOPLASTIC CEREBELLAR DEGENERATION

It is the most common remote effect of neoplasm affecting the brain.
It is associated with lung, ovarian, and breast Ca and Hodgkin’s disease.
Histopathologically, there is a severe loss of Purkinje cells.
Two main antibodies are found in patient’s sera and CSF; namely Yo and Hu antibodies.
The symptoms usually progress rapidly to severe and symmetric truncal and limb ataxia with dysarthria and nystagmus.
Cerebellar sypmtoms may improve in some patients when causative neoplasms are removed.